反应详情

To a solution of 2-hydroxy-methyl-5-methoxy-pyridine (0.68 g, 4.9 mmol) in dry DCM was added dropwise excess thionyl chloride (2.0 mL), and the mixture was refluxed for 2 hours. The solvent was removed in vacuo, and the residue was taken up in EtOAc and washed with NaHCO3 (aq), dried (MgSO4, and concentrated in vacuo. The extremely volatile 2-chloromethyl-5-methoxy-pyridine was obtained as a solution in ethyl acetate to give (984.0 mg, 83.5%) yield.

1. temperaturethe mixture was refluxed for 2 hours
2. customThe solvent was removed in vacuo
3. washwashed with NaHCO3 (aq)
4. dry with materialdried (MgSO4
5. concentrationconcentrated in vacuo