HCID 9859160, compound → HCID 9904219, compound

Participants

Reaction Steps

To a solution of methyl 5-(1,2-dihydroxypropyl)-2-pyridinecarboxylate (6 mg) in pyridine (0.1 ml), acetic anhydride (50 μl) was added at room temperature. After stirring for 1 hour at room temperature, the reaction mixture was evaporated under N2 gas. The residue was applied to a silica gel plate (Kiesselgel GF254, 10×10 cm, Merck trademark) and developed with chloroform-methanol (95:5) to give methyl 5-(1,2-diacetoxypropyl)-2-pyridinecarboxylate: white amorphous powder; molecular formula C14H17NO6; LRFAB-MS m/z 296 [M+H]+; 1H-NMR (CDCl3) δ 8.68 (1 H, d, J=2.2 Hz), 8.16 (1H, d, J=8.1 Hz), 8.03 (1 H, dd, J=8.1 and 2.2 Hz), 5.95 (1 H, d, J=4.3 Hz), 5.28 (1H, dq, J=6.5 and 4.3 Hz), 3.97 (3H, s), 2.12 (3H, s), 1.99 (3H, s), 1.18 (3H, d, J=6.5 Hz).

Provenance & Evidence