Phenylcyanamide → HCID 178479311, compound

HRID 636679Notes

Reaction equation

HRID 636679 reaction equation
[ClH:1].[NH2:2][C:3]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]=1.[C:19]1([NH:25][C:26]#[N:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(#N)C>[ClH:1].[NH2:2][C:3]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:26]([NH:25][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[NH:27])=[CH:12][CH:13]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]=1

Participants

4

Reactant 2

HCID 69318PhenylcyanamideHCID 18522077HCID 18522077, compound

Product 1

HCID 178479311HCID 178479311, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-Amino-N-(4-aminophenyl)benzimidazole hydrochloride (1.58 g, 6.06 mmol), phenylcyanamide (2.79 g, 23.6 mmol) and acetonitrile (10 ml) was refluxed for 3 days. The solid product was filtered off. The product was recrystallized from acetonitrile (300 ml). Yield 1.3 g, 57%. M.p. 265-267° C.

Workup

  1. temperaturewas refluxed for 3 days
  2. filtrationThe solid product was filtered off
  3. customThe product was recrystallized from acetonitrile (300 ml)

Sources & evidence

ORD record
ord-fdc67e4c114142c39a699d3398a655cb
Source dataset
uspto-grants-2001_02
Patent number
US06194447B1

Reaction notes

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