Water → HCID 53844281, compound

Participants

Reaction Steps

14.0 g (47.9 mM) of 3-[2-(2-phenyl-4-oxazolyl)ethoxy]benzaldehyde, prepared as described in Preparation 2 herein, was diluted with 200 mL i-PrOH and treated with 2.89 g (76.6 mM) of sodium borohydride. The mixture was stirred at ambient temperature for 24 hr. 250 mL of H2O was added slowly over a period of 1 hr to quench the reaction and the resulting mixture was stirred for 1 hr. It was then concentrated under reduced pressure and the residue was diluted with 300 mL EtOAc and washed with H2O (300 mL) and brine (300 mL). All the organics were combined, dried over MgSO4, and concentrated to yield 13.6 g of a yellow waxy solid.

Provenance & Evidence