Sodium Hydroxide → HCID 9821018, compound

Participants

Reaction Steps

A solution of N-[3-cyano-4-(4-hydroxy-3-isopropyl-phenoxy)-5-methyl-phenyl]-oxamic acid ethyl ester (110 mg) and 1N aqueous sodium hydroxide (0.6 mL) in EtOH (1 mL) was stirred at ambient temperature for 10 min, partitioned between ethyl acetate/1N aqueous hydrochloric acid, the organic layer washed with brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound as a colorless solid (9 mg). MS: 353.

Provenance & Evidence