反应详情

温度

5 °C

To a suspension of 2,4-difluorobenzaldehyde (608.9 mg, 4.28 mmol), 1,1-dimethylnitroethane (881.9 mg, 8.55 mmol) and zinc (840.0 mg, 12.8 mmol) in ethanol (15 ml) was added acetic acid (1.54 g, 25.6 mmol) dropwise at 5° C. while stirring. The mixture was stirred at room temperature for one day. After the mixture was cooled to 5° C., zinc acetate was filtered off and the filtrate was concentrated and purified by silica gel chromatography (hexane/ethyl acetate=4/1).

1. stirringThe mixture was stirred at room temperature for one day
2. filtrationzinc acetate was filtered off
3. concentrationthe filtrate was concentrated
4. custompurified by silica gel chromatography (hexane/ethyl acetate=4/1)