反应详情

To a suspension of 2,4-dichlorobenzaldehyde (462.1 mg, 2.64 mmol), 1,1-dimethylnitroethane (543.1 mg, 5.27 mmol) and zinc (514.8 mg, 7.88 mmol) in ethanol (3.0 ml) was added acetic acid (944.8 mg, 15.7 mmol) dropwise at 5° C. while stirring. The mixture was stirred at room temperature for one day. Zinc acetate was filtered off and the filtrate was concentrated and purified by silica gel chromatography (hexane/ethyl acetate=5/1).

1. stirringThe mixture was stirred at room temperature for one day
2. filtrationZinc acetate was filtered off
3. concentrationthe filtrate was concentrated
4. custompurified by silica gel chromatography (hexane/ethyl acetate=5/1)