反应详情

To a suspension of 2-fluorobenzaldehyde (332.3 mg, 2.68 mmol), 1,1-dimethylnitroethane (547.5 mg, 5.31 mmol) and zinc (514.6 mg, 7.87 mmol) in ethanol (3.0 ml) was added acetic acid (940.2 mg, 15.7 mmol) dropwise at 5° C. while stirring. The mixture was stirred at room temperature for 6.5 hours. Zinc acetate in the mixture was filtered off and the filtrate was concentrated and purified by silica gel chromatography (hexane/ethyl acetate=4/1 to 2/1).

1. stirringThe mixture was stirred at room temperature for 6.5 hours
2. filtrationZinc acetate in the mixture was filtered off
3. concentrationthe filtrate was concentrated
4. custompurified by silica gel chromatography (hexane/ethyl acetate=4/1 to 2/1)