反应详情

To a suspension of 2,6-difluorobenzaldehyde (374.7 mg, 2.64 mmol), 1,1-dimethylnitroethane (541.6 mg, 5.25 mmol) and zinc (517.0 mg, 7.91 mmol) in ethanol (3.0 ml) was added acetic acid (940.5 mg, 15.7 mmol) dropwise at 5° C. while stirring. The mixture was stirred at room temperature for 5 hours. Zinc acetate in the mixture was filtered off and the filtrate was concentrated and purified by silica gel chromatography (hexane/ethyl acetate=5/2-2/1).

1. stirringThe mixture was stirred at room temperature for 5 hours
2. filtrationZinc acetate in the mixture was filtered off
3. concentrationthe filtrate was concentrated
4. custompurified by silica gel chromatography (hexane/ethyl acetate=5/2-2/1)