反应详情

To a solution of the obtained 2-amino-2-methyl-1-methoxypropane hydrochloride (422 mg, 2.08 mmol) in toluene (7 ml) was added 2,4-difluorobenzaldehyde (310 mg, 2.18 mmol) and stirred under reflux using a Dean-Stark trap to remove water for 1 hour. Then triethylamine (1.0 ml) was added to the mixture and stirred for 6 hours. The precipitated hydrochloride was filtered off and the solvent was evaporated to give the crude title compound (547.5 mg).

1. temperatureunder reflux
2. customto remove water for 1 hour
3. additionThen triethylamine (1.0 ml) was added to the mixture
4. stirringstirred for 6 hours
5. filtrationThe precipitated hydrochloride was filtered off
6. customthe solvent was evaporated