Sodium Bicarbonate → HCID 16771440, compound

Participants

Reaction Steps

A solution of the obtained N-(2,4-difluorobenzylidene)-t-butylamine in methanol (5 ml) was cooled to 0° C. in ice-water bath. To the solution was added NaBH4 (138.3 mg, 3.65 mmol). The mixture was gradually warmed to room temperature and stirred for 2.5 hours. The mixture was added to sat. NaHCO3 aqueous solution, extracted three times with ethyl acetate and dried over MgSO4. The mixture was concentrated and purified by silica gel chromatography (hexane/ethyl acetate/triethylamine=100/5/1) to give the title compound (504.2 mg; 83%, 2 steps).

Provenance & Evidence