2-Methoxybenzoyl chloride → 1-(2-methoxyphenyl)-1-oxo-2-aza-4-(R)-ethyl-4-phenylbutane

HRID 636759Notes

Reaction equation

HRID 636759 reaction equation
[C:1]1([C@@H:7]([CH2:10][CH3:11])[CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17]>>[CH3:12][O:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](=[O:17])[CH2:11][CH2:10][C@@H:7]([CH2:8][NH2:9])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 889692-Methoxybenzoyl chlorideHCID 6993012(2R)-2-phenylbutan-1-amine

Product 1

HCID 693356791-(2-methoxyphenyl)-1-oxo-2-aza-4-(R)-ethyl-4-phenylbutane

Procedure

The title compound was prepared from 0.2 gm of (R)-(−)-2-phenylbutyl amine and 2-mL of 4 methoxybenzoyl chloride according to procedures described in Example 2.

Sources & evidence

ORD record
ord-8b06200c802f4a238cfcdbbb2e19237a
Source dataset
uspto-grants-2001_02
Patent number
US06194458B1

Reaction notes

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