HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-cyclopropylethan-1-one → 4-(Trifluoromethyl)thiazole-2-carboximidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-cyclopropylethan-1-one | HCID 10920841 | — |
| Reactant | 2-Bromo-4-(trifluoromethyl)-1,3-thiazole | HCID 23149887 | — |
| Reactant | 4-Cyclopropyl-thiazole-2-carboxamidine | HCID 90000916 | — |
| Product | 4-(Trifluoromethyl)thiazole-2-carboximidamide | HCID 58282745 | — |
Reaction Steps
4-Trifluoromethyl-thiazole-2-carboxamidine (Compound U) was prepared in analogy to Compound M with procedure shown in Example 10 by using 2-bromo-4-trifluoromethyl-thiazole (CAS: 41731-39-9) instead of 2-bromo-4-cyclopropyl-thiazole which is made from 2-bromo-1-cyclopropyl-ethanone in Example 10. MS: calc'd (MH+) 196, measured (MH+) 196.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447086B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-c893a4a227fa4434867d182a34a06ca9 |
| Source note | uspto-grants-2016_09 |