Dimethylsulphamoyl chloride → HCID 70224742, compound

HRID 636805Notes

Reaction equation

[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:5](=[CH:14][C:15]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)=[O:16])[NH:4][C:3]1([CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.[CH3:39][N:40]([CH3:45])[S:41](Cl)(=[O:43])=[O:42]>>[CH3:39][N:40]([CH3:45])[S:41]([N:11]1[CH2:12][CH2:13][CH:8]([CH2:7][N:6]2[C:2](=[O:1])[C:3]([CH2:25][C:26]3[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=3)([CH2:32][C:33]3[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=3)[NH:4][C:5]2=[CH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=2)=[O:16])[CH2:9][CH2:10]1)(=[O:43])=[O:42]

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 70225437HCID 70225437, compound

Product 1

HCID 70224742HCID 70224742, compound

Procedure

According to the procedure of Example 13, the title compound of 40B (50 mg, 0.099 mmol) and N,N-dimethylsulfamyl chloride (0.025 ml, 0.237 mmol) were reacted to generate the title compound as a white solid (14 mg, 0.023 mmol, 19% yield).

Sources & evidence

ORD record: ord-378a0673bdb54d2d951a10ae866f208c
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06194438B1

Reaction notes

Loading…