1-methyl-1H-imidazole-4-sulfonyl chloride → HCID 70224741, compound

HRID 636807Notes

Reaction equation

HRID 636807 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:5](=[CH:14][C:15]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)=[O:16])[NH:4][C:3]1([CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.[CH3:39][N:40]1[CH:44]=[C:43]([S:45](Cl)(=[O:47])=[O:46])[N:42]=[CH:41]1>>[CH3:39][N:40]1[CH:44]=[C:43]([S:45]([N:11]2[CH2:12][CH2:13][CH:8]([CH2:7][N:6]3[C:2](=[O:1])[C:3]([CH2:25][C:26]4[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=4)([CH2:32][C:33]4[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=4)[NH:4][C:5]3=[CH:14][C:15]([C:17]3[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=3)=[O:16])[CH2:9][CH2:10]2)(=[O:47])=[O:46])[N:42]=[CH:41]1

Participants

3

Reactant 2

HCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 70225437HCID 70225437, compound

Product 1

HCID 70224741HCID 70224741, compound

Procedure

According to the procedure of Example 13, the title compound of 40B (100 mg, 0.20 mmol) and 1-methylimidazol-4-ylsulfonyl chloride (50 mg, 0.30 mmol) were reacted to generate the title compound as a white solid (9 mg, 0.014 mmol, 7% yield).

Sources & evidence

ORD record
ord-4840004b7c87496fb74381afbd264676
Source dataset
uspto-grants-2001_02
Patent number
US06194438B1

Reaction notes

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