Benzenesulfonyl chloride → HCID 70225072, compound

HRID 636811Notes

Reaction equation

[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:12][CH2:11][NH:10][CH2:9]2)[C:5](=[CH:13][C:14]([C:16]2[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=2)=[O:15])[NH:4][C:3]1([CH2:31][C:32]1[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=1)[CH2:24][C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1.[C:38]1([S:44](Cl)(=[O:46])=[O:45])[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[C:38]1([S:44]([N:10]2[CH2:11][CH2:12][CH:8]([CH2:7][N:6]3[C:2](=[O:1])[C:3]([CH2:24][C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)([CH2:31][C:32]4[CH:33]=[CH:34][N:35]=[CH:36][CH:37]=4)[NH:4][C:5]3=[CH:13][C:14]([C:16]3[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=3)=[O:15])[CH2:9]2)(=[O:46])=[O:45])[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 70225090HCID 70225090, compound

Product 1

HCID 70225072HCID 70225072, compound

Procedure

According to the procedure of Example 13, the title compound of 46B (100 mg, 0.20 mmol) and benzenesulfonyl chloride (0.04 ml, 0.198 mmol) were reacted to generate the title compound of Example 46 as a white solid (25 mg, 0.037 mmol, 37% yield).

Sources & evidence

ORD record: ord-da391f47aa22451db7a2052eff4f19eb
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06194438B1

Reaction notes

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