Water → 5-Fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione;palladium

Participants

Reaction Conditions

Reaction Steps

Palladium dibromide (0.377 g) is dissolved in 30% aqueous ammonium hydroxide (50 g) in a 250-mL flask equipped with a magnetic stir bar. Deionized water (60 g) is added to the solution, followed by addition of TS-1 (30 g, 2.12 wt. % titanium) over a 5 minute period. The slurry is stirred at 23° C. for 0.5 hr, then the solvent is removed by rotoevaporation at 55° C. The solids are dried in a vacuum oven (1 torr) at 50° C. for 4 hrs. The catalyst (Catalyst 3) analyzed for 0.5 wt % palladium, 2.1 wt % titanium, 0.7 wt % bromine and 0.37 wt % nitrogen.

Provenance & Evidence