HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 2-Diethylphosphinoylmethyl-1,3-dioxolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 3-Bromo-1,2-propanediol | HCID 20827 | — |
| Reactant | Diethyl (2,2-diethoxyethyl)phosphonate | HCID 82071 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Product | 2-Diethylphosphinoylmethyl-1,3-dioxolane | HCID 21255858 | — |
Reaction Steps
Diethylphosphonoacetaldehyde diethylacetal (VIIa) was condensed with 3-bromo-1,2-propanediol (Va) in the presence of p-toluenesulfonic acid as a catalyst and reflux in toluene to yield 2-diethylphosphinoylmethyl-1,3-dioxolane of formula (IId) as a mixture of cis and trans isomers;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194576B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-bed6440a0ef748faba594c4ac88553a7 |
| Source note | uspto-grants-2001_02 |