HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → HCID 73331551, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | (S)-morpholine-3-carboxylic acid | HCID 1501894 | — |
| Reactant | 1-Methyl-1H-imidazole-2-carbonitrile | HCID 10953443 | — |
| Reactant | 2-Chloro-3-fluorobenzaldehyde | HCID 14944905 | — |
| Reactant | 1,3-Thiazole-2-carbonitrile | HCID 15111480 | — |
| Reactant | 4,4-Difluoroproline | HCID 15216102 | — |
| Product | HCID 73331551 | HCID 73331551 | — |
Reaction Steps
The title compound was prepared in analogy to Example 2 with Procedure B shown in Scheme 5 by using 2-chloro-3-fluoro-benzaldehyde, ethyl acetoacetate, 1-methyl-1H-imidazole-2-carbonitrile and (S)-morpholine-3-carboxylic acid instead of 2-chloro-4-fluoro-benzaldehyde, methyl acetoacetate, thiazole-2-carbonitrile and (S)-4,4-difluoro-pyrrolidine-2-carboxylic acid. The stereochemistry of Example 97 was determined by comparing its 1H NMR data and HPLC retention time with Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447086B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-2099ff62d97b47c7bf9b35d3db29fc75 |
| Source note | uspto-grants-2016_09 |