7-methoxynaphthalene-2-sulfonyl Chloride → HCID 69780705, compound

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Reaction Steps

Using the procedure described for 11a, the reaction of methyl ester 1j and sulfonyl chloride 12a gave 3-(1-amino-6-isoquinolinyl)-2-[[(7-methoxy-2-naphthalenyl)sulfonyl)amino]propionic acid methyl ester. This ester was saponified and subsequently coupled with 4-methylpiperidine using the procedure described for the previous example to give the title compound 12b. 1H-NMR 200 MHz (CD3OD) δ: 0.18-0.85 (5H, m), 1.22-1.58 (3H, m), 1.78-3.18 (4H, m), 3.80-4.26 (2H, m), 3.88 (3H, s), 4.57-4.72 (1H, m), 6.97-7.04 (1H, m), 7.20-7.79 (8H, m), 8.01-8.14 (2H, m).

Provenance & Evidence