4-(Tetrahydropyran-4-yloxymethyl)-benzenesulfonyl chloride → N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxymethyl)-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	4-(Tetrahydropyran-4-yloxymethyl)-benzenesulfonyl chloride	HCID 22665672	—
Reactant	N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide	HCID 22665795	—
Product	N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxymethyl)-benzenesulfonamide	HCID 22665794	—

Reaction Steps

This compound was prepared from 218 mg of 4-(tetrahydropyran-4-yloxymethyl)-benzene-sulfonyl chloride and 210 mg (0.5 mmol) 30a using the procedure described for 58c. Yield: 100 mg, m.p. 124-128° C., (+)-FAB-MS: 573 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06194409B1
Source dataset	uspto-grants-2001_02
ORD ID	ord-22ccf9638a554479baa669d452261a64
Source note	uspto-grants-2001_02