HRID636940

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22507216

4-(2-Methoxyethoxy)benzene-1-sulfonyl chloride

C9H11ClO4S

结构：CC1CCN(C(=O)C(Cc2cc3c(N)nccc3s2)NS(=O)(=O)c2ccc(OC3CCOCC3)cc2)CC1

HCID22665795

N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide

C27H34N4O5S2

PRODUCTS

生成物

结构：COCCOc1ccc(S(=O)(=O)NC(Cc2cc3c(N)nccc3s2)C(=O)N2CCC(C)CC2)cc1

HCID22665719

未命名化合物

PROCEDURE

实验过程

This compound was prepared from 0.6 mmol 4-(2-methoxy-ethoxy)-benzenesulfonyl chloride and 210 mg (0.5 mmol) of 30a using the procedure described for 58c . Yield: 30 mg (white crystals), m.p. 210° C. (decomp.), EI-MS: 532 (M+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ebdbedbd9a8441da8c47c6216c96c9ae
来源数据集: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06194409B1
来源说明: uspto-grants-2001_02

反应 SMILES

[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1.[NH2:16][C:17]1[C:22]2[CH:23]=[C:24]([CH2:26][CH:27]([NH:37]S(C3C=CC(OC4CCOCC4)=CC=3)(=O)=O)[C:28]([N:30]3[CH2:35][CH2:34][CH:33]([CH3:36])[CH2:32][CH2:31]3)=[O:29])[S:25][C:21]=2[CH:20]=[CH:19][N:18]=1>>[NH2:16][C:17]1[C:22]2[CH:23]=[C:24]([CH2:26][CH:27]([NH:37][S:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:7][CH:8]=3)(=[O:14])=[O:13])[C:28]([N:30]3[CH2:31][CH2:32][CH:33]([CH3:36])[CH2:34][CH2:35]3)=[O:29])[S:25][C:21]=2[CH:20]=[CH:19][N:18]=1