2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride → 2,3-Dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride	HCID 22665777	—
Reactant	N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide	HCID 22665795	—
Product	2,3-Dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide	HCID 86756459	—

Reaction Steps

This compound was prepared from 200 mg of 2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride and 210 mg of 30a using the procedure described for 58c. Yield: 80 mg (oil), (+)-FAB-MS: 530 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06194409B1
Source dataset	uspto-grants-2001_02
ORD ID	ord-00de4be4d7004028895f56f24d5a8d38
Source note	uspto-grants-2001_02