Aluminium lithium hydride → 4-Benzyl-7-methoxy-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

HRID 636958Notes

Reaction equation

HRID 636958 reaction equation
[CH2:1]([N:8]1[CH2:14][C:13]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:12]=2[O:11][CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(N1CC2C=CC=CC=2OCC1)C1C=CC=CC=1>>[CH2:1]([N:8]1[CH2:14][C:13]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:12]=2[O:11][CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 21226445Aluminium lithium hydrideHCID 22665701HCID 22665701, compoundHCID 226659024-Benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

Product 1

HCID 226657064-Benzyl-7-methoxy-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

Procedure

This compound was prepared from 5.7 g of 4-benzyl-7-methoxy-4,5-dihydro-benzo[f][1,4]-oxazepin-3-one and 2.3 g of lithium aluminum hydride using the procedure described for 64d. Yield: 6.1 g (oil), EI-MS: 269 (M+).

Sources & evidence

ORD record
ord-958705c12b834a8f9d842c127d0a26fa
Source dataset
uspto-grants-2001_02
Patent number
US06194409B1

Reaction notes

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