HuagongsheHuagongshe Chemistry Print Report · For research reference only
Proline benzyl ester hydrochloride → 1-[(R)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Proline benzyl ester hydrochloride | HCID 2733413 | — |
| Reactant | (alphaR)-alpha-((Methoxycarbonyl)amino)benzeneacetic acid | HCID 10910775 | — |
| Product | 1-[(S)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester | HCID 54280769 | 15% |
| Product | 1-[(R)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester | HCID 54280770 | 31% |
Reaction Steps
Reaction of 1.0 g of (R)-methoxycarbonylamino-phenyl-acetic acid and 1.16 g of (L)-proline benzyl ester hydrochloride according to the procedure described in example 91b gave 0.59 g (31%) of the title compound as a white solid and 0.28 g (15%) of 1-[(S)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester (+)-APCI-MS: 397 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194409B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-8f1fa657399b4eae8bd46494ec3502ab |
| Source note | uspto-grants-2001_02 |