HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen iodide → 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | Emedastine EP Impurity E | HCID 9984168 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane hydriodic acid salt | HCID 86583887 | — |
Reaction Steps
Alternately, combine 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (18.42 g, 63.9 mmol), 57% hydriodic acid (8.30 mL), ethanol (80 mL) and stir. After 2.5 hours, cool to give a solid. Collect the solid by filtration, rinse with diethyl ether, and dry in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194406B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-d9671426e0904e118e7e695abccbd2c7 |
| Source note | uspto-grants-2001_02 |