HuagongsheHuagongshe Chemistry Print Report · For research reference only
Emedastine EP Impurity E → 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethyoxyethyl)-1H-benzimidazol-2-yl) 1,4 diazepan-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Emedastine EP Impurity E | HCID 9984168 | — |
| Reactant | 3-(3,4-Dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)-3-pyrrolidineethanol methansulfonate | HCID 15840899 | — |
| Product | 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethyoxyethyl)-1H-benzimidazol-2-yl) 1,4 diazepan-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine | HCID 18464603 | — |
Reaction Steps
Prepare by the method of Example 1.6 using 1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-methanesulfonyloxyethyl)pyrrolidine and 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194406B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-3bfcde793c7249979ef5a44debc5da02 |
| Source note | uspto-grants-2001_02 |