HuagongsheHuagongshe Chemistry Print Report · For research reference only
Emedastine EP Impurity E → HCID 18464462, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Emedastine EP Impurity E | HCID 9984168 | — |
| Reactant | 1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidine | HCID 18464483 | — |
| Product | HCID 18464462 | HCID 18464462 | — |
Reaction Steps
Prepare by the method of Example 1.6 using 1-(3,4,5-trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidine and 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane to give the title compound: Rf=0.39 (silica gel, 2% triethylamine/20% methanol/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194406B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-ba5df40cb5804fc7a89b06657a82d853 |
| Source note | uspto-grants-2001_02 |