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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 637055Generated: October 30, 2026

Emedastine EP Impurity E → 1-(3,4,5-Trimethoxybenzyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-(phenylmethyl)-5-oxopyrrolidine

https://huagongshe.com/reaction/637055

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEmedastine EP Impurity EHCID 9984168—
Reactant1-(3,4,5-Trimethoxybenzyl)-3-(2-methanesulfonyloxyethyl)-3-(phenylmethyl)-5-oxopyrrolidineHCID 18465102—
Product1-(3,4,5-Trimethoxybenzyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-(phenylmethyl)-5-oxopyrrolidineHCID 18464871—

Reaction Steps

Prepare by the method of Example 1.6 using 1-(3,4,5-trimethoxybenzyl)-3-(2-methanesulfonyloxyethyl)-3-(phenylmethyl)-5-oxopyrrolidine and 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06194406B1
Source datasetuspto-grants-2001_02
ORD IDord-192f0ab18e75420fa1fe366c4337db3f
Source noteuspto-grants-2001_02