HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 1-(5-(ethoxycarbonyl)fur-2-ylmethyl)-2-chloro-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | Ethyl 5-(chloromethyl)-2-furancarboxylate | HCID 263166 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(5-(ethoxycarbonyl)fur-2-ylmethyl)-2-chloro-1H-benzimidazole | HCID 18464972 | — |
Reaction Steps
Alternately, combine 2-chlorobenzimidazole (20 mmol) and sodium hydride (20 mmol) in dimethylformamide (30 mL). After gas evolution ceases, add ethyl 5-chloromethyl-2-furoate (20 mmol) and stir. After 1 day, evaporate in vacuo to give a residue. Combine the residue and ethyl acetate. Extract with water and brine. Dry the the organic layer over Na2SO4, filter, and evaporate in vacuo to give 1-(5-(ethoxycarbonyl)fur-2-ylmethyl)-2-chloro-1H-benzimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194406B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-f4fe41e9f6d946489d18272e3957f972 |
| Source note | uspto-grants-2001_02 |