Hydrochloric Acid → 2-chloro-3,4,5-trimethoxybenzoic Acid

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Reaction Steps

Combine methyl 2-chloro-3,4,5-trimethoxybenzoate (2.0 g, 7.8 mmol) and a 1 M aqueous solution of sodium hydroxide (100 mL, 100 mmol) in methanol (50 mL). After 6 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with dichloromethane. Dry the combined organic layers over MgSO4, filter, and concentrate in vacuo to give the title compound; Rf=0.81 (silica gel, 10% ethanol/85% chloroform/5% acetic acid).

Provenance & Evidence