Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

HRID 637199Notes

Reaction equation

HRID 637199 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][O:7]C1CCCCO1.[Br-].[Mg+2].[Br-]>C(OCC)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][OH:7]

Participants

4

Reactant 2

HCID 82241Magnesium BromideHCID 184646842-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether

Product 1

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluoroethyl ether.

Workup

  1. extractionextract with water
  2. dry with materialDry the organic layer over Na2SO4
  3. filtrationfilter
  4. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-ccf83556c6c9485698554d785da3e684
Source dataset
uspto-grants-2001_02
Patent number
US06194406B1

Reaction notes

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