HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperidine → 11-[2-(2-methylpiperidin-1-yl)acetyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperidine | HCID 7974 | — |
| Reactant | 11-(chloroacetyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | HCID 19804217 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 11-[2-(2-methylpiperidin-1-yl)acetyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | HCID 20256757 | 37.2% |
Reaction Steps
A suspension of 11-(2-chloroacetyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one (2.9 g) and 2-methylpiperidine (2.37 ml) in dioxane (30 ml) was refluxed under stirred for two hours. After cooling and filtration, the collected solid was crystallized from absolute ethanol to give 1.3 g (37.2%) of 11-[2-(2-methylpiperidin-1-yl)acetyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one melting at 248°-249° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04556653 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-cdc1ba043d5e43c782f566179b40e664 |
| Source note | uspto-grants-1985_12 |