Cyclopropylamine → HCID 178471877, compound

Participants

Reaction Steps

23.2 g of cyclopropylamine are added dropwise to a solution of 123.9 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-ethoxyacrylate (5) in 250 ml of ethanol, while cooling with ice and stirring. When the exothermic reaction has abated, stirring is continued for a further hour at room temperature, the solvent is stripped off in vacuo and the residue is recrystallised from cyclohexane petroleum ether. 115 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylamino-acrylate (6) of melting point 63°-65° C. are obtained.

Provenance & Evidence