Formaldehyde → HCID 13815987, compound

HRID 637308Notes

Reaction equation

HRID 637308 reaction equation
[N:1]1([C:6]2[CH:20]=[CH:19][C:9]([C:10]([C:12]3[NH:13][C:14](=[O:18])[NH:15][C:16]=3[CH3:17])=[O:11])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[CH2:21]=[O:22]>>[OH:22][CH2:21][C:2]1[N:1]([C:6]2[CH:20]=[CH:19][C:9]([C:10]([C:12]3[NH:13][C:14](=[O:18])[NH:15][C:16]=3[CH3:17])=[O:11])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 367855HCID 367855, compound

Product 1

HCID 13815987HCID 13815987, compound

Conditions

Temperature
120 °C

Procedure

1,3-Dihydro-4-[4-(1H-imidazol-1-yl)benzoyl]-5-methyl-2H-imidazol-2-one (5.85 g, 21.8 mmol) (Example I) is combined in a pressure tube containing a magnetic stir bar with 37% aqueous formaldehyde (300 mL) and the mixture heated with stirring at 120° C. for 18 hr. The mixture is cooled, the tube opened and the solution evaporated in vacuo. Chromatography of the residue on silica gel affords the title compound.

Workup

  1. temperaturethe mixture heated
  2. temperatureThe mixture is cooled
  3. customthe solution evaporated in vacuo

Sources & evidence

ORD record
ord-8456f1ec881f46e5917f38498764971a
Source dataset
uspto-grants-1985_12
Patent number
US04556665

Reaction notes

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