HCID 13192322, compound → HCID 13192321, compound

HRID 637312Notes

Reaction equation

HRID 637312 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([C:12]1[S:16][C:15]2=[N:17][CH2:18][CH2:19][N:14]2[C:13]=1[CH3:20])=[O:11]>O>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([C:12]1[S:16][C:15]2=[N:17][CH2:18][CH2:19][N:14]2[C:13]=1[CH3:20])=[O:11]

Participants

3

Reactant 1

HCID 13192322HCID 13192322, compound2×

Product 1

HCID 13192321HCID 13192321, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-(2-chlorophenylcarbamoyl)-3-methyl-5,6-dihydro-imidazo [2,1-b] thiazole hydrochloride (compound 4) (8.2 g, 0.025M) was dissolved in water (250 ml) and the insolubes were removed by filtration. To the solution was added 5% sodium hydroxide solution with stirring until an alkaline pH (pH 9-11) was reached. The precipitated crystals were filtered, washed and dried to obtain compound 3 as white powdery crystals. (7.2 g, yield: 98.2%).

Workup

  1. customthe insolubes were removed by filtration
  2. additionTo the solution was added 5% sodium hydroxide solution
  3. filtrationThe precipitated crystals were filtered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-69f1a55669c44c358641d9e7e266b38d
Source dataset
uspto-grants-1985_12
Patent number
US04556669

Reaction notes

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