Bromine → HCID 13563091, compound

Participants

Reaction Steps

6'-Fluoro-spiro[imidazolidine-4,1'-indan]-2,5-dione, (C.A. reg. no. 66892-38-4)(1.1 g, 5 mmol) was combined with 2.65 ml (10 mmol) bis-(trimethylsilyl) trifluoroacetamide, 0.8 g (5 mmol) bromine and 30 ml ethylene dichloride and heated at reflux for 2.5 hours. During this time color was lost from the reaction mixture. The reaction mixture was concentrated in vacuo to an amber oil which was diluted with 10 ml water. Over a period of 16 hours at 25° C. a solid gradually formed. This material was isolated by filtration and dried in vacuo at 100° C. to give 1.0 g (85% yield) of the title compound: mp 209°-211° C.

Provenance & Evidence