Ethanol → HCID 13563087, compound

Participants

Reaction Steps

m-Methoxybenzene-gamma-oxo-butanoic acid (C.A. reg. no. 38102-67-9) (10.0 g, 48 mmol) was combined with 22.75 g (235 mmol) ammonium carbonate, 6.5 g (100 mmol) potassium cyanide in 100 ml ethanol and 100 ml water at 65° C. After 5 hours at 65° C. an additional 22.75 g (235 mmol) ammonium carbonate was added and heating was continued for 18 hours. The reaction mixture was concentrated in vacuo, triturated with water and the acidity was adjusted to pH 4 with concentrated hydrochloric acid. A white solid formed which was collected by filtration and dried in vacuo at 80° C. for 20 hours to give 10.6 g (79% yield) of the title compound: mp 138° C.

Provenance & Evidence