Acetic Anhydride → HCID 12551451, compound

HRID 637321Notes

Reaction equation

HRID 637321 reaction equation
[NH2:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:3]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>ClCCl>[C:14]([NH:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:3]=1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 125514501-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine

Product 1

HCID 12551451HCID 12551451, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Amino-1-(p-chlorophenyl)-2-pyrazoline (5 g) was added to acetic anhydride (4.0 ml) at room temperature. On stirring with a glass rod the mixture became warm and afforded a dark red liquid. The mixture was taken up in dichloromethane (100 ml) washed (water, 100 ml; saturated sodium bicarbonate, 100 ml; water, 100 ml), dried over sodium sulphate and the solvent removed in vacuo to afford the title compound (m.p. 171°-173°).

Workup

  1. temperaturebecame warm
  2. customafforded a dark red liquid
  3. washwashed (water, 100 ml; saturated sodium bicarbonate, 100 ml; water, 100 ml)
  4. dry with materialdried over sodium sulphate
  5. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-70c060365a714a58bd72b7fa33a2d5f5
Source dataset
uspto-grants-1985_12
Patent number
US04556671

Reaction notes

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