p-Toluenesulfonic acid → HCID 70490786, compound

Participants

Reaction Steps

A mixture of 9.67 g of the product of Step A, 80 mg of p-toluene sulfonic acid and 120 ml of benzene was refluxed and 60 ml of benzene were distilled over 90 minutes equipped with a flask of Dean Stark apparatus containing silica gel. The mixture was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a 6-4 hexane-ethyl acetate mixture yielded 7.36 of 6,6-dimethyl-4-[methylthio-ethoxycarbonyl-methyl]-3-oxa-bicyclo [3,1,0]-hexane-2-one.

Provenance & Evidence