反应详情

温度

36 °C

A mixture of 4-phenyl-pyrrolidin-2-one (32.2 g; 0.2 mole), dimethyl sulfate (37.8 g; 0.3 mole), tetrabutyl ammonium hydrogensulfate (3.4 g; 0.01 mole), 50% aqueous sodium hydroxide solution (100 ml) and toluene (200 ml) is stirred at 36° C. for 5 hrs. After cooling, the aqueous phase is decanted, extracted with methylene chloride, and combined with the toluene phase. The organic phase is washed with water, dried and evaporated. The residue is distilled: b.p.0.2 mm Hg =120° C. Yield: 79%.

1. temperatureAfter cooling
2. customthe aqueous phase is decanted
3. extractionextracted with methylene chloride
4. washThe organic phase is washed with water
5. customdried
6. customevaporated
7. distillationThe residue is distilled
8. customb.p.0.2 mm Hg =120° C