N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-diacetoxy-2-propoxymethyl)guanine → N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-dihydroxy-2-propoxymethyl)guanine

HRID 637338노트

반응식

HRID 637338 반응식
[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:24][C:25]2[NH:26][C:27](=[O:47])[C:28]3[N:29]=[CH:30][N:31]([CH2:34][O:35][CH:36]([CH2:42][O:43]C(=O)C)[CH2:37][O:38]C(=O)C)[C:32]=3[N:33]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][CH:6]=1>CO.[OH-].[NH4+]>[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH:24][C:25]2[NH:26][C:27](=[O:47])[C:28]3[N:29]=[CH:30][N:31]([CH2:34][O:35][CH:36]([CH2:37][OH:38])[CH2:42][OH:43])[C:32]=3[N:33]=2)([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:9][CH:10]=1

참가 물질

4

반응물 1

HCID 136387274N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-diacetoxy-2-propoxymethyl)guanine

생성물 1

HCID 136387272N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-dihydroxy-2-propoxymethyl)guanine

시약·촉매·용매 2

HCID 887Methanol용매HCID 14923Ammonium Hydroxide용매2회

반응 조건

온도
50 °C

실험 절차

4.0 G of N2 -(4-methoxyphenyldiphenylmethyl)-9-(1,3-diacetoxy-2-propoxymethyl)guanine in 100 ml of methanol plus 20 ml of concentrated ammonium hydroxide was magnetically stirred at 22° C. for 16 hours then at 50° C. for 2.5 hours. An additional 10 ml of ammonium hydroxide were then added and the solution stirred another 2.5 hours at 50° C. Next, the solution was concentrated at reduced pressure and the residual solid recrystallized from methanol:ethyl acetate to give 3.5 g of N2 -(4-methoxyphenyldiphenylmethyl)-9-(1,3-dihydroxy-2-propoxymethyl)guanine, m.p. 148°-151° C.

후처리

  1. concentrationNext, the solution was concentrated at reduced pressure
  2. customthe residual solid recrystallized from methanol

출처 및 근거

ORD 기록
ord-3524762787c54ad7b3cf8f4536a6e443
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556659

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