HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic anhydride → 5-Chloro-2-oxo-2,3-dihydro-1H-indole-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 2-(5-Chloro-2-ureidophenyl)acetic acid | HCID 13647655 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5-Chloro-2-oxo-2,3-dihydro-1H-indole-1-carboxamide | HCID 9859159 | 1.8% |
Reaction Steps
Cyclization of 4.78 g (0.021 mole) of 2-(5-chloro-2-ureidophenyl)acetic acid with 8.0 g (0.063 mole) of trifluoroacetic anhydride in 75 ml of trifluoroacetic acid, according to the method of Example 13, followed by recrystallization of the crude product from acetonitrile, gave 80 mg of the title compound, m.p. 211° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04556672 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-dc73f182a51a4b2888b213ef6c85235b |
| Source note | uspto-grants-1985_12 |