Diisopropylethylamine → (S)-2-[[1-(4-azidobutyl)cyclopentanecarbony]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 2733084	—
Reactant	1-(4-Azidobutyl)cyclopentanecarboxylic acid	HCID 22660141	—
Reactant	(S)-2-amino-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester	HCID 86691352	—
Product	(S)-2-[[1-(4-azidobutyl)cyclopentanecarbony]amino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester	HCID 89720754	—

Reaction Steps

The title compound was prepared using a similar procedure as described in Example 1, Step 8, starting from (S)-2-amino-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester (10.78 g, 30 mmol), 1-[4-azidobutyl]cyclopentanecarboxylic acid (8.24 g, 39 mmol), HBTU (14.79 g, 39 mmol), and DIPEA (11.63 g, 15.68 mL, 90 mmol), and after ISCO column chromatography purification, resulted in an amorphous off-white solid (14.1 g, 85%). ES(+)-HRMS m/e calcd. for C29H40N6O5 (M+H)+ 553.3133, obsd. 553.3133.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09447035B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-f7989408f3af4032a0c63967aca3019f
Source note	uspto-grants-2016_09