Benzoyl chloride → HCID 13647646, compound

HRID 637355Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([NH2:13])=[O:12])[C:6](=[O:14])[CH2:5]2.[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:15]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([NH2:13])=[O:12])[C:6](=[O:14])[CH2:5]2)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 13647649HCID 13647649, compound

Product 1

HCID 13647646HCID 13647646, compoundYield 90%

Procedure

Acylation of 5-amino-2-oxindole-1-carboxamide with benzoyl chloride substantially according to the procedure of Example 31 afforded a 90% yield of the title compound as a cream-colored solid, mp 223°-226° C.

Sources & evidence

ORD record: ord-c746f0ba8c2a45c5b9918397355cd493
Source dataset: uspto-grants-1985_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04556672

Reaction notes

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