Acetonitrile → HCID 13647447, compound

HRID 637356Notes

Reaction equation

HRID 637356 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[NH:10][C:9]1=[O:18])=[O:7].ClS([N:23]=[C:24]=[O:25])(=O)=O.C(#N)C>O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[N:10]([C:24]([NH2:23])=[O:25])[C:9]1=[O:18])=[O:7]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 70918Chlorosulfonyl isocyanateHCID 135656636-Fluoro-3-(furan-2-carbonyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 13647447HCID 13647447, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Following substantially the procedure of Example 24, the title compound was prepared in 17% yield from 3-(2-furoyl)-6-fluoro-2-oxindole (0.30 g, 1.2 mmole), chlorosulfonyl isocyanate (0.20 g, 1.4 mmole), acetonitrile (15 ml) and water (10 ml). Yield=60 mg, m.p. 231°-235° C.

Sources & evidence

ORD record
ord-c516dc9cd8324067be07527ed1263d15
Source dataset
uspto-grants-1985_12
Patent number
US04556672

Reaction notes

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