HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → 5,6-difluoro-2,3-dihydro-1H-indole-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Product | 5,6-difluoro-2,3-dihydro-1H-indole-2,3-dione | HCID 1926308 | — |
Reaction Steps
Reaction of 3,4-difluoroaniline with chloral hydrate and hydroxylamine followed cyclization with sulfuric acid, in a manner analogous to Parts A and B of Preparation 9, gave 5,6-difluoroisatin, which was reacted with hydrazine hydrate followed by sodium methoxide in ethanol, in a manner analogous to Preparation 7, to give the title compound, m.p. 187°-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04556672 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-38a54e7d39f540bf946c56541ab62c0c |
| Source note | uspto-grants-1985_12 |