反应详情

The mixture of 4.9 g (0.02 mol) of α-cyclopentyl-p-methoxy butyrophenone, 8.0 g (0.06 mol) of aluminium trichloride and 60 ml of benzene was refluxed for 3 hours. Dilute hydrochloric acid was added, the layers separated and the organic layer washed with water. The product was extracted with 2M sodium hydroxide. The alkaline solution was made acidic. The product was extracted with methylene chloride, dried and the solvent evaporated. The residue 4.1 g (0.018 mol, 88%) was crystallized from petroleum ether. Mp. 75°-78° C.

1. temperaturewas refluxed for 3 hours
2. customthe layers separated
3. washthe organic layer washed with water
4. extractionThe product was extracted with 2M sodium hydroxide
5. extractionThe product was extracted with methylene chloride
6. customdried
7. customthe solvent evaporated