HCID 20256923, compound → HCID 20256917, compound

Participants

Reaction Steps

10.7 g (0.038 mol) of ethyl 2-ethyl-3-hydroxy-3-(p-methoxyphenyl)pentanoate were hydrogenated in acetic acid (88 ml) solution in the presence of methanesulfonic acid (7 drops) by using 10% Pd-C as catalyst. The catalyst was filtered off and the solvent was evaporated. The product was dissolved in methylene chloride, washed with diluted potassium carbonate and water and dried. After evaporation of the solvent 9,5 g (97%) of the product as a mixture of erythro and threo diastereomers were obtained.

Provenance & Evidence