Trifluoroacetic acid → (S)-2-[4-(3-aminopropoxy)-2,6-dichlorobenzoylamino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl]propionic acid propyl ester trifluoroacetate salt

Participants

Reaction Steps

The title compound was prepared using a similar procedure as described in Example 5, Step 6, starting from (S)-2-[4-(3-tert-butoxycarbonylaminopropoxy)-2,6-dichlorobenzoylamino]-3-[4-(1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5- yl)phenyl]propionic acid propyl ester (781 mg, 1.1 mmol) and TFA (1.14 g, 742 uL, 10 mmol), resulting in a hygroscopic white solid (790 mg, 99%). ES(+)-HRMS m/e calcd. for C29H34Cl2N4O6 (M+H)+ 605.1928, obsd. 605.1929.

Provenance & Evidence